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Article

PharmVar GeneFocus: NAT2-Genetic Variation and Updated Nomenclature.

Clinical pharmacology and therapeutics - 1 Apr 2026

Papanikolaou Georgia, Poloni Estella S, Agúndez José A G, Teixeira Raquel L F, Boone Erin C, Rezende Santos Adalberto, Whirl-Carrillo Michelle, Sangkuhl Katrin, Klein Teri E, Habil Mariam R, Fakis Giannoulis, Minchin Rodney F, Hein David W, Boukouvala Sotiria, Gaedigk Andrea

Abstract excerpt

The Pharmacogene Variation Consortium (PharmVar) provides nomenclature for the highly polymorphic human N-acetyltransferase 2 (NAT2) gene. NAT2 metabolizes several clinically used drugs including isoniazid, hydralazine, amifampridine, procainamide, and sulfonamides such as dapsone, and also some highly carcinogenic arylamines. Systematic nomenclature describing NAT2 variation is essential for pharmacogenetic...

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Identifiers

PMID: 41432551
DOI: 10.1002/cpt.70168
PMCID: PMC12997514

Genes

NAT2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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