Article
ERE-independent ERalpha target genes differentially expressed in human breast tumors.
Molecular and cellular endocrinology - 21 Dec 2005
Glidewell-Kenney Christine, Weiss Jeffrey, Lee Eun-Jig, Pillai Suresh, Ishikawa Toshio, Ariazi Eric A, Jameson J Larry
Abstract excerpt
The classical pathway for estrogen receptor (ER) signaling is mediated by ER binding to an estrogen response element (ERE) in DNA. ERalpha can also act via a nonclassical pathway by altering the activities of other transcription factors (e.g., Sp1, AP-1, or NF-kappaB) at their cognate sites on DNA. We previously generated a mutant form of ERalpha (E207A/G208A) that does not bind to EREs, and therefore lacks...
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