Article
An estrogen receptor-alpha knock-in mutation provides evidence of ligand-independent signaling and allows modulation of ligand-induced pathways in vivo.
Endocrinology - 1 Jun 2008
Sinkevicius Kerstin W, Burdette Joanna E, Woloszyn Karolina, Hewitt Sylvia C, Hamilton Katherine, Sugg Sonia L, Temple Karla A, Wondisford Fredric E, Korach Kenneth S, Woodruff Teresa K, Greene Geoffrey L
Abstract excerpt
Estrogen-nonresponsive estrogen receptor-alpha (ERalpha) knock-in (ENERKI) mice were generated to distinguish between ligand-induced and ligand-independent ER-alpha actions in vivo. These mice have a mutation [glycine 525 to leucine (G525L)] in the ligand-binding domain of ERalpha, which significantly reduces ERalpha interaction with and response to endogenous estrogens, whereas not affecting growth factor...
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