Article
An estrogen receptor (ER)alpha deoxyribonucleic acid-binding domain knock-in mutation provides evidence for nonclassical ER pathway signaling in vivo.
Molecular endocrinology (Baltimore, Md.) - 1 Oct 2002
Jakacka Monika, Ito Masafumi, Martinson Fred, Ishikawa Toshio, Lee Eun Jig, Jameson J Larry
Abstract excerpt
We created a nonclassical estrogen receptor (ER) knock-in mouse model by introducing a mutation that selectively eliminates classical ER signaling through estrogen response elements, while preserving the nonclassical ER pathway. Heterozygous nonclassical ER knock-in (NERKI) females are infertile. Their ovaries contain no corpora lutea, reflecting a defect in ovulation, and the stromal cells contain lipid...
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