Article
Estrogen receptor binding to DNA is not required for its activity through the nonclassical AP1 pathway.
The Journal of biological chemistry - 27 Apr 2001
Jakacka M, Ito M, Weiss J, Chien P Y, Gehm B D, Jameson J L
Abstract excerpt
In the classical signaling pathway, the estrogen receptor (ER) binds directly to estrogen response elements (EREs) to regulate gene transcription. To test the hypothesis that the nonclassical pathway involves ER interactions with other proteins rather than direct binding to DNA, mutations were introduced into the DNA binding domain (DBD) of the mouse ERalpha. The effects of these DBD mutations were examined in...
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