Initiation of DNA interstrand cross-link repair in humans: the nucleotide excision repair system makes dual incisions 5' to the cross-linked base and removes a 22- to 28-nucleotide-long damage-free strand.

doi:10.1128/MCB.17.12.6822

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Article

Initiation of DNA interstrand cross-link repair in humans: the nucleotide excision repair system makes dual incisions 5' to the cross-linked base and removes a 22- to 28-nucleotide-long damage-free strand.

Molecular and cellular biology - 1 Dec 1997

Bessho T, Mu D, Sancar A

Abstract excerpt

Most DNA repair mechanisms rely on the redundant information inherent to the duplex to remove damaged nucleotides and replace them with normal ones, using the complementary strand as a template. Interstrand cross-links pose a unique challenge to the DNA repair machinery because both strands are d...

Topics

Animals
Base Sequence
CHO Cells
Cell Line
Cricetinae
Cross-Linking Reagents
DNA
DNA Damage
DNA Ligases
DNA Repair
DNA, Circular
Endodeoxyribonucleases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Escherichia coli Proteins

Furocoumarins

Humans

Intercalating Agents

Models, Biological

Molecular Sequence Data

Source

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Identifiers

PMID: 9372913
DOI: 10.1128/MCB.17.12.6822
PMCID: PMC232538

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9372913-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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