Article
Reduced ligation during DNA base excision repair supported by BRCA2 mutant cells.
Oncogene - 23 Nov 2000
Bogliolo M, Taylor R M, Caldecott K W, Frosina G
Abstract excerpt
The breast cancer predisposing genes BRCA1 and BRCA2 appear to be involved in DNA repair. In particular, the sensitivity of BRCA2-deficient mouse embryonic fibroblasts to ionizing radiation and the demonstrated interaction of the BRCA2 protein with Rad51, a major factor in recombinational repair, indicate that BRCA2 is important for double strand break repair. The human BRCA2-deficient human cell line Capan-1,...
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