Article
DNA repair fidelity of base excision repair pathways in human cell extracts.
DNA repair - 3 Feb 2005
Zhang Qiu-Mei, Dianov Grigory L
Abstract excerpt
Base excision repair (BER), responsible for the removal of altered DNA bases, is accomplished via two pathways that involve different subsets of repair enzymes and result in removal and replacement of one (short-patch BER) or several (long-patch BER) nucleotides. In this study, we constructed single-lesion containing DNA substrates that are predominantly repaired via one of the two pathways and investigated the...
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