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Article

IL-6 knockout mice exhibit resistance to stress-induced development of depression-like behaviors.

Neurobiology of disease - 1 Sept 2006

Chourbaji Sabine, Urani Alexandre, Inta Ioana, Sanchis-Segura Carles, Brandwein Christiane, Zink Mathias, Schwaninger Markus, Gass Peter

Abstract excerpt

Cytokine-dependent mechanisms in the CNS have been implicated in the pathogenesis of depression. Interleukin-6 is upregulated in depressed patients and dowregulated by antidepressants. It is, however, unknown whether IL-6 is involved in the pathogenesis of depression. We subjected IL-6-deficient mice (IL-6(-/-)) to depression-related tests (learned helplessness, forced swimming, tail suspension, sucrose...

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Source

Identifiers

PMID: 16843000
DOI: 10.1016/j.nbd.2006.05.001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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