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Article

Suppression of NLRP3 inflammasome attenuates stress-induced depression-like behavior in NLGN3-deficient mice.

Biochemical and biophysical research communications - 2 Jul 2018

Li Ze-Qun, Yan Zhi-Yuan, Lan Fu-Jun, Dong Yi-Qun, Xiong Ye

Abstract excerpt

Depression, regulated by central nervous system (CNS), is a significant inflammatory disorder. Neuroligin3 (NLGN3) has been implicated in brain functions. In the study, a chronic unpredictable mild stress (CUMS) model in wild type (WT) or NLGN3-knockout (KO) mice was established to explore the role of NLGN3 in regulating depression and to reveal the underlying molecular mechanism. The results indicated that...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 29775613
DOI: 10.1016/j.bbrc.2018.05.085

Genes

NLGN3
NLRP3
BDNF
CORT
FST
GFAP
TNF
TST

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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