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Article

Targeting classical IL-6 signalling or IL-6 trans-signalling in depression?

Expert opinion on therapeutic targets - 1 May 2014

Maes Michael, Anderson George, Kubera Marta, Berk Michael

Abstract excerpt

INTRODUCTION: Increased IL-6 and soluble IL-6 receptor (sIL-6R) levels in depressed patients was first shown over 20 years ago. The pro-inflammatory effects of IL-6 are predominantly mediated by IL-6 trans-signalling via the sIL-6R, whereas IL-6R membrane signalling has anti-inflammatory effects. AREAS COVERED: We review data on IL-6 and sIL-6R in inflammation, depression, animal models of depression and the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 24548241
DOI: 10.1517/14728222.2014.888417

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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