Article
Possible involvement of signal transducers and activators of transcription 3 system on depression in the model mice brain.
Biological & pharmaceutical bulletin - 1 Jan 2010
Mingmalairak Salin, Tohda Michihisa, Murakami Yukihisa, Matsumoto Kinzo
Abstract excerpt
The aim of this study was to examine gene expression changes in the frontal cortex and hippocampus of animals with different susceptibility to stressful stimuli. Using a learned helplessness (LH) paradigm, mice received moderate current stimulation to induce different extents of LH behavior. Changes in mRNA expression were investigated by microarray and semiquantitative reverse transcription-polymerase chain...
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