Article
Differential modulation of GR signaling and HDACs in the development of resilient/vulnerable phenotype and antidepressant-like response of vorinostat.
Psychoneuroendocrinology - 1 Feb 2021
K V Athira, Wahul Abhipradnya Bipin, Soren Kalyani, Das Tapatee, Dey Sandeep, Samudrala Pavan Kumar, Kumar Arvind, Lahkar Mangala, Chakravarty Sumana
Abstract excerpt
The present study explored the antidepressant potential of vorinostat (VOR) against chronic social defeat stress (CSDS) in mice. Since this model has the remarkable capacity to delineate the resilient and the defeated mice, we also looked for their molecular deviations. Defeated mice showed classical phenotypic alterations such as anhedonia, social avoidance, anxiety and despair. Whereas, resilient mice were...
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