Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Inflammatory Factors Predicted the Resilient Phenotype in Social Defeat-induced Depression of Male Mouse.

Neuroscience - 21 May 2023

Li Long, Ma Shanbo, Wang Jin, Chen Yuhan, Wang Feiyan, Zheng Meiling, Zhang Kun, Miao Shan, Shi Xiaopeng

Abstract excerpt

An absence of reward in chronic stress may impair the reward circuit in the brain, resulting in major depressive disorder (MDD). In a part of chronically stressed individuals, MDD is not present, i.e., there is resilience, implying endogenous anti-depressive mechanisms in the brain. We studied social defeat model mice and analyzed the mRNA maps of the hippocampus from a control group and social defeat...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Depressive Disorder, Major
Share to Fluoxetine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mice, Inbred C57BL

Share to Minocycline

Share to Phenotype

Share to Social Behavior

Share to Stress, Psychological

Source

Identifiers

PMID: 36893981
DOI: 10.1016/j.neuroscience.2023.02.022

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Inflammatory Factors Predicted the Resilient Phenotype in Social Defeat-induced Depression of Male Mouse.PMID 36893981Read ↗

Transcriptomic analyses of humans and mice provide insights into depression.Semantic proximity Read ↗

Molecular mechanism of reward treatment ameliorating chronic stress-induced depressive-like behavior assessed by sequencing miRNA and mRNA in medial prefrontal cortexSemantic proximity Read ↗

Differential modulation of GR signaling and HDACs in the development of resilient/vulnerable phenotype and antidepressant-like response of vorinostat.Semantic proximity Read ↗

Enriched environment mitigates depressive behavior by changing the inflammatory activation phenotype of microglia in the hippocampus of depression model rats.Semantic proximity Read ↗

IGF2 inhibits hippocampal over-activated microglia and alleviates depression-like behavior in LPS- treated male mice.Semantic proximity Read ↗

Systematical comparison reveals distinct brain transcriptomic features in models of depression induced by gut microbiota dysbiosis and chronic stressSemantic proximity Read ↗

Ketogenic diet alters microglial morphology and changes the hippocampal lipidomic profile distinctively in stress susceptible <i>versus</i> resistant male mice upon repeated social defeatSemantic proximity Read ↗

Prolonged chronic social defeat stress promotes less resilience and higher uniformity in depression-like behaviors in adult male mice.Semantic proximity Read ↗

Inflammation and depression.Semantic proximity Read ↗

Single-cell mass cytometry of microglia in major depressive disorder reveals a non-inflammatory phenotype with increased homeostatic marker expression.Semantic proximity Read ↗

Dynamic alterations of depressive-like behaviors, gut microbiome, and fecal metabolome in social defeat stress miceSemantic proximity Read ↗

Beneficial effects of anti-RANKL antibody in depression-like phenotype, inflammatory bone markers, and bone mineral density in male susceptible mice after chronic social defeat stress.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.