IL-6 deficiency leads to increased emotionality in mice: evidence in transgenic mice carrying a null mutation for IL-6.

doi:10.1016/s0165-5728(98)00199-4

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Article

IL-6 deficiency leads to increased emotionality in mice: evidence in transgenic mice carrying a null mutation for IL-6.

Journal of neuroimmunology - 1 Dec 1998

Armario A, Hernández J, Bluethmann H, Hidalgo J

Abstract excerpt

The role of interleukin-6 (IL-6) on emotional behavior was studied in two experiments using transgenic mice carrying a null mutation for IL-6 (IL-6(-/-)). In the first experiment, IL-6(-/-) mice were compared with the two wild-type strains contributing to the genetic background of the transgenic...

Topics

Animals
Behavior, Animal
Emotions
Exploratory Behavior
Interleukin-6
Maze Learning
Mice
Mice, Inbred Strains
Mice, Knockout
Mice, Transgenic
Motor Activity
Mutation
Sexual Behavior, Animal

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