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Article

Multidrug Resistance: Retrospect and Prospects in Anti-Cancer Drug Treatment

10 Jun 2006

Abstract excerpt

Conventional cancer chemotherapy is seriously limited by the multidrug resistance (MDR) commonly exhibited by tumour cells. One mechanism by which a living cell can achieve multiple resistances is via the active efflux of a broad range of anticancer drugs through the cellular membrane by MDR proteins. Such drugs are exported in both ATP-dependent and -independent manners, and can occur despite considerable...

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PMID: 16842198
DOI: 10.2174/092986706777585077

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