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Overcoming multidrug resistance through targeting ABC transporters: lessons for drug discovery

22 Aug 2022

Abstract excerpt

INTRODUCTION: The argument around cancer therapy is an old one. Using chemotherapeutic drugs, as one of the most effective strategies in treatment of malignancies, is restricted by various issues that progress during therapy and avoid achieving clinical endpoints. Multidrug resistance (MDR), frequently mediated by ATP-binding cassette (ABC) transporters, is one of the most recognized obstacles in the success of...

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PMID: 35996765
DOI: 10.1080/17460441.2022.2112666

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