The Emergence of Drug Transporter-Mediated Multidrug Resistance to Cancer Chemotherapy

doi:10.1021/mp200261n

Article

The Emergence of Drug Transporter-Mediated Multidrug Resistance to Cancer Chemotherapy

19 Jul 2011

Abstract excerpt

Chemotherapy is currently one of the most effective ways to treat metastatic cancers. However, of the various mechanisms that are involved in conferring resistance, upregulation of drug efflux ATP-binding cassette (ABC) transporters, such as P-glycoprotein (ABCB1), multidrug resistance protein 1 (ABCC1) and ABCG2, has become a major obstacle to cancer chemotherapy and seriously affects the clinical outcome. To...

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