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Revisiting the ABCs of Multidrug Resistance in Cancer Chemotherapy

28 Mar 2011

Abstract excerpt

The adenosine triphosphate binding cassette (ABC) transporters are one of the largest transmembrane gene families in humans. The ABC transporters are present in a number of tissues, providing protection against xenobiotics and certain endogenous molecules. Unfortunately, their presence produces suboptimal chemotherapeutic outcomes in cancer patient tumor cells. It is well established that they actively efflux...

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PMID: 21118094
DOI: 10.2174/138920111795164048

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