Article
Integration of Human Immunodeficiency Virus Type 1 in Untreated Infection Occurs Preferentially within Genes
13 Jul 2006
Abstract excerpt
Previous analyses of human immunodeficiency virus type 1 (HIV-1) integration sites generated in infections in vitro or in patients in whom viral replication was repressed by antiviral therapy have demonstrated a preference for integration within protein-coding genes. We analyzed integration sites in peripheral blood mononuclear cells (PBMCs), spleen, lymph node, and cerebral cortex from patients with untreated...
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