HIV Insertions Within and Proximal to Host Cell Genes Are a Common Finding in Tissues Containing High Levels of HIV DNA and Macrophage-Associated p24 Antigen Expression

Abstract excerpt

HIV integration within host cell genomic DNA is a requisite step of the viral infection cycle. Yet, characteristics of the sites of provirus integration within the host genome remain obscure. The authors present evidence that in diseased tissues showing a high level of HIV DNA and macrophage-associated HIV p24 antigen expression from end stage forms of HIV disease, HIV-1 integration sites were favored within...

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