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HIV-1 integration sites in CD4+ T cells during primary, chronic, and late presentation of HIV-1 infection

30 Mar 2021

Abstract excerpt

HIV-1 is capable of integrating its genome into that of its host cell. We examined the influence of the activation state of CD4+ T cells, the effect of antiretroviral therapy (ART), and the clinical stage of HIV-1 infection on HIV-1 integration site features and selection. HIV-1 integration sites were sequenced from longitudinally sampled resting and activated CD4+ T cells from 12 HIV-1-infected individuals. In...

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PMID: 33784259
DOI: 10.1172/jci.insight.143940

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