Article

Target site selection of retroviral vectors in the human genome : viral and genomic determinants of non-random integration patterns in hematopoietic cells

2008-01-01

Abstract excerpt

Integration of gamma-retroviruses (RV) and lentiviruses (LV) follows different, non-random patterns in mammalian genomes. To obtain information about the viral and genomic determinants of integration preferences, I mapped > 2,500 integration sites of RV and LV vectors carrying wild type or modified LTRs in human CD34<sup>+</sup> hematopoietic cells. Recurrent insertion sites (hot spots) account for > 20% of the RV...

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Literature Corpus work: e3c45539-c64b-5bba-a9a9-7ede6a80c27e
DOI: 10.21954/ou.ro.0000f263

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