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Article

Activation of the phosphatidylinositol 3-kinase Vps34 by a G protein alpha subunit at the endosome.

Cell - 14 Jul 2006

Slessareva Janna E, Routt Sheri M, Temple Brenda, Bankaitis Vytas A, Dohlman Henrik G

Abstract excerpt

In the yeast Saccharomyces cerevisiae, the G protein beta gamma subunits are essential for pheromone signaling. The Galpha subunit Gpa1 can also promote signaling, but the effectors in this pathway are not well characterized. To identify candidate Gpa1 effectors, we expressed the constitutively active Gpa1(Q323L) mutant in each of nearly 5000 gene-deletion strains and measured mating-specific responses. Our...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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PMID: 16839886
DOI: 10.1016/j.cell.2006.04.045

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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