Article
A polymorphism of MS4A2 (- 109T > C) encoding the beta-chain of the high-affinity immunoglobulin E receptor (FcepsilonR1beta) is associated with a susceptibility to aspirin-intolerant asthma.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology - 1 Jul 2006
Kim S-H, Bae J-S, Holloway J W, Lee J-T, Suh C-H, Nahm D-H, Park H-S
Abstract excerpt
BACKGROUND AND OBJECTIVE: The MS4A2 gene, the beta chain of the high-affinity receptor for immunoglobulin (Ig)E, has previously been linked to atopy and asthma. The beta-chain of FcepsilonR1 enhances receptor maturation and signal transduction capacity, leading to the release of proinflammatory mediators and cytokines that can exacerbate the symptom of asthma. This study was performed to evaluate whether two...
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