Article
Association and functional relevance of E237G, a polymorphism of the high-affinity immunoglobulin E-receptor beta chain gene, to airway hyper-responsiveness.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology - 1 Apr 2007
Kim Y-K, Park H-W, Yang J-S, Oh S-Y, Chang Y-S, Shin E-S, Lee J-E, Kim S, Gho Y S, Cho S-H, Min K-U, Kim Y-Y
Abstract excerpt
BACKGROUND: The hyper-sensitivity reaction of IgE, with its high-affinity receptors (FcepsilonRI), is central to the phenomenon of atopic diseases. OBJECTIVE: To evaluate the genetic effects of non-synonymous single-nucleotide polymorphisms (SNPs) of FcepsilonRI on intermediate phenotypes of asthma, i.e. atopy and airway hyper-responsiveness (AHR), in the Korean general population. SUBJECTS AND METHODS: Atopy and...
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