Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Site-directed mutagenesis of CC chemokine receptor 1 reveals the mechanism of action of UCB 35625, a small molecule chemokine receptor antagonist.

The Journal of biological chemistry - 11 Feb 2005

de Mendonça Filipa Lopes, da Fonseca Paula C A, Phillips Rhian M, Saldanha José W, Williams Timothy J, Pease James E

Abstract excerpt

The chemokine receptor CCR1 and its principal ligand, CCL3/MIP-1alpha, have been implicated in the pathology of several inflammatory diseases including rheumatoid arthritis, multiple sclerosis, and asthma. As such, these molecules are the focus of much research with the ultimate aim of developing...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Binding, Competitive
Share to Chemotaxis
Share to Glutamic Acid

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Inflammation

Share to Models, Chemical

Share to Protein Structure, Secondary

Share to Receptors, Chemokine

Share to Stereoisomerism

Source

Identifiers

PMID: 15548526
DOI: 10.1074/jbc.M412267200

Genes

CCR1
CCL3
MIP

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-15548526-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Site-directed mutagenesis of CC chemokine receptor 1 reveals the mechanism of action of UCB 35625, a small molecule chemokine receptor antagonist.PMID 15548526Read ↗

The Expanding Therapeutic Perspective of CCR5 BlockadeSemantic proximity Read ↗

Analysis of the Mechanism by Which the Small-Molecule CCR5 Antagonists SCH-351125 and SCH-350581 Inhibit Human Immunodeficiency Virus Type 1 EntrySemantic proximity Read ↗

Predictions of CCR1 chemokine receptor structure and BX 471 antagonist binding followed by experimental validation.Semantic proximity Read ↗

Noncanonical roles of chemokine regions in CCR9 activation revealed by structural modeling and mutational mappingSemantic proximity Read ↗

Site-directed mutagenesis of the CC chemokine binding protein 35K-Fc reveals residues essential for activity and mutations that increase the potency of CC chemokine blockade.Semantic proximity Read ↗

Noncanonical roles of chemokine regions in CCR9 activation revealed by structural modeling and mutational mappingSemantic proximity Read ↗

Comparison of the potential multiple binding modes of bicyclam, monocylam, and noncyclam small-molecule CXC chemokine receptor 4 inhibitors.Semantic proximity Read ↗

Variants of CCR5, which are permissive for HIV-1 infection, show distinct functional responses to CCL3, CCL4 and CCL5.Semantic proximity Read ↗

Identification of overlapping but differential binding sites for the high-affinity CXCR3 antagonists NBI-74330 and VUF11211.Semantic proximity Read ↗

Targeting chemokine receptors in disease – a case study of CCR4Semantic proximity Read ↗

Positive versus negative modulation of different endogenous chemokines for CC-chemokine receptor 1 by small molecule agonists through allosteric versus orthosteric binding.Semantic proximity Read ↗

Molecular determinants of antagonist interactions with chemokine receptors CCR2 and CCR5Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.