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Article

Ligand- and mutation-induced conformational selection in the CCR5 chemokine G protein-coupled receptor.

Proceedings of the National Academy of Sciences of the United States of America - 9 Sept 2014

Abrol Ravinder, Trzaskowski Bartosz, Goddard William A, Nesterov Alexandre, Olave Ivan, Irons Christopher

Abstract excerpt

We predicted the structural basis for pleiotropic signaling of the C-C chemokine type 5 (CCR5) G protein-coupled receptor (GPCR) by predicting the binding of several ligands to the lower-energy conformations of the CCR5 receptor and 11 mutants. For each case, we predicted the ∼ 20 most stable conformations for the receptor along with the binding sites for four anti-HIV ligands. We found that none of the ligands...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25157173
DOI: 10.1073/pnas.1413216111
PMCID: PMC4246978

Genes

CCR5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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