Genetic variation in insulin receptor beta-chain exons among members of familial type 2 (non-insulin-dependent) diabetic pedigrees.

doi:10.1007/BF00401521

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Article

Genetic variation in insulin receptor beta-chain exons among members of familial type 2 (non-insulin-dependent) diabetic pedigrees.

Diabetologia - 1 Oct 1991

Elbein S C, Sorensen L K

Abstract excerpt

Insulin resistance appears to be an essential component of Type 2 (non-insulin-dependent) diabetes mellitus. Both hyperinsulinaemia and insulin resistance are inherited and may precede the onset of Type 2 diabetes. To determine whether insulin receptor gene mutations, and specifically whether mutations of the beta-chain could account for the observed insulin resistance, we studied members of 16 pedigrees...

Topics

Amino Acid Sequence
Base Sequence
DNA
Diabetes Mellitus, Type 2
Exons
Female
Genetic Variation
Humans
Introns
Macromolecular Substances
Male
Middle Aged

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Nucleic Acid Conformation

Pedigree

Polymerase Chain Reaction

Polymorphism, Restriction Fragment Length

Receptor, Insulin

Source

Open in PubMed

Identifiers

PMID: 1683636
DOI: 10.1007/BF00401521

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1683636-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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