Article
Insulin resistance and diabetes due to different mutations in the tyrosine kinase domain of both insulin receptor gene alleles.
The Journal of biological chemistry - 15 Mar 1991
Kusari J, Takata Y, Hatada E, Freidenberg G, Kolterman O, Olefsky J M
Abstract excerpt
Mutations in the insulin receptor gene can lead to in vivo and in vitro insulin resistance and can be the cause of diabetes mellitus in selected patients. We have studied a 22-year-old diabetic woman with Type A insulin resistance and acanthosis nigricans. Insulin binding to the patient's erythro...
Topics
- Adult
- Alleles
- Amino Acid Sequence
- Base Sequence
- DNA
- Diabetes Mellitus
- Female
- Humans
- Insulin Resistance
- Molecular Sequence Data
- Mutation
- Nucleic Acid Hybridization
- Pedigree
- Phosphorylation
- Protein-Tyrosine Kinases
- Receptor, Insulin