Article
The amino acid sequence of the insulin receptor is normal in an insulin-resistant Pima Indian.
The Journal of clinical endocrinology and metabolism - 1 Apr 1990
Cama A, Patterson A P, Kadowaki T, Kadowaki H, Siegel G, D'Ambrosio D, Lillioja S, Roth J, Taylor S I
Abstract excerpt
Insulin resistance is an early predictor of development of noninsulin-dependent diabetes mellitus (NIDDM) in Pima Indians, a population with the highest reported prevalence of NIDDM. The insulin receptor plays a central role in mediating insulin action, and previous studies have demonstrated that...
Topics
- Adult
- Alleles
- Amino Acid Sequence
- Base Sequence
- Cloning, Molecular
- DNA
- Diabetes Mellitus, Type 2
- Exons
- Humans
- Indians, North American
- Insulin Resistance
- Male
- Molecular Sequence Data
- Pedigree
- Polymerase Chain Reaction
- Receptor, Insulin