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Article

The amino acid sequence of the insulin receptor is normal in an insulin-resistant Pima Indian.

The Journal of clinical endocrinology and metabolism - 1 Apr 1990

Cama A, Patterson A P, Kadowaki T, Kadowaki H, Siegel G, D'Ambrosio D, Lillioja S, Roth J, Taylor S I

Abstract excerpt

Insulin resistance is an early predictor of development of noninsulin-dependent diabetes mellitus (NIDDM) in Pima Indians, a population with the highest reported prevalence of NIDDM. The insulin receptor plays a central role in mediating insulin action, and previous studies have demonstrated that mutations in the insulin receptor gene may cause insulin resistance. Therefore, we have cloned the insulin receptor...

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Source

Identifiers

PMID: 2318937
DOI: 10.1210/jcem-70-4-1155

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The amino acid sequence of the insulin receptor is normal in an insulin-resistant Pima Indian.PMID 2318937Read ↗

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The role of insulin receptor substrate-1 gene (IRS1) in type 2 diabetes in Pima Indians.Semantic proximity Read ↗

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A naturally occurring mutation of insulin receptor alanine 1134 impairs tyrosine kinase function and is associated with dominantly inherited insulin resistance.Semantic proximity Read ↗

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