Article
Insulin-resistant diabetes associated with partial deletion of insulin-receptor gene.
Lancet (London, England) - 19 May 1990
Shimada F, Taira M, Suzuki Y, Hashimoto N, Nozaki O, Taira M, Tatibana M, Ebina Y, Tawata M, Onaya T
Abstract excerpt
The insulin-receptor genes from a 16-year-old girl with type A insulin resistance, who presented with fasting hyperinsulinaemia, acanthosis nigricans, and reduced insulin binding, and from her family were examined. One allele of her insulin-receptor gene inherited from her mother contained a 1.2...
Topics
- Adolescent
- Adult
- Aged
- Alleles
- Chromosome Deletion
- Chromosome Mapping
- DNA
- Diabetes Mellitus
- Exons
- Female
- Genetic Carrier Screening
- Glucose Tolerance Test
- Humans
- Insulin Resistance
- Male
- Mutation
- Pedigree
- Polymorphism, Restriction Fragment Length