Article
Polymorphisms in candidate genes for type 2 diabetes mellitus in a Mexican population with metabolic syndrome findings.
Diabetes research and clinical practice - 1 Jan 2004
Sánchez-Corona J, Flores-Martínez S E, Machorro-Lazo M V, Galaviz-Hernández C, Morán-Moguel M C, Perea F J, Mújica-López K I, Vargas-Ancona L, Laviada-Molina H A, Fernández V, Pardío J, Arroyo P, Barrera H, Hanson R L
Abstract excerpt
The metabolic or insulin resistance syndrome, characterized by hypertension, dyslipidemia, glucose intolerance and hyperinsulinemia, may have genetic determinants. The insulin gene (INS), insulin receptor gene (INSR) and insulin receptor substrate 1 gene (IRS1) have been proposed as candidate genes. We examined eight polymorphisms in these genes in 163 individuals from Yucatan, Mexico; this population has a high...
Topics
- Adolescent
- Adult
- Alleles
- Case-Control Studies
- Diabetes Mellitus, Type 2
- Female
- Gene Frequency
- Humans
- Hypercholesterolemia
- Hyperinsulinism