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Article

Multisite phosphorylation of doublecortin by cyclin-dependent kinase 5.

The Biochemical journal - 15 Jul 2004

Graham Mark E, Ruma-Haynes Patricia, Capes-Davis Amanda G, Dunn Joanne M, Tan Timothy C, Valova Valentina A, Robinson Phillip J, Jeffrey Peter L

Abstract excerpt

Doublecortin (DCX) is a 40 kDa microtubule-associated protein required for normal neural migration and cortical layering during development. Mutations in the human DCX gene cause a disruption of cortical neuronal migration. Defects in cdk5 (cyclin-dependent kinase 5) also cause defects in neural...

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Source

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Identifiers

PMID: 15099191
DOI: 10.1042/BJ20040324
PMCID: PMC1133854

Genes

DCX

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-15099191-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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Multisite phosphorylation of doublecortin by cyclin-dependent kinase 5.PMID 15099191Read ↗

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Doublecortin microtubule affinity is regulated by a balance of kinase and phosphatase activity at the leading edge of migrating neurons.Semantic proximity Read ↗

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