Article
A study of genetic linkage heterogeneity in 35 adult-onset polycystic kidney disease families.
Human genetics - 1 Jan 1993
Wright A F, Teague P W, Pound S E, Pignatelli P M, Macnicol A M, Carothers A D, De Mey R J, Allan P L, Watson M L
Abstract excerpt
A genetic heterogeneity analysis of 35 kindreds with adult-onset polycystic kidney disease (ADPKD) was carried out using the D16S85, D16S84, D16S125 and D16S94 loci that are closely linked to the PKD1 locus on chromosome 16. The results show that the likelihood of two ADPKD loci is 2,514.9 times...
Topics
- Adult
- Chi-Square Distribution
- Chromosomes, Human, Pair 16
- Female
- Genetic Linkage
- Genetic Testing
- Genetic Variation
- Genotype
- Humans
- Likelihood Functions
- Male
- Polycystic Kidney, Autosomal Dominant