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Article

Modifier effect of the Toll-like receptor 4 D299G polymorphism in children with cystic fibrosis.

Archivum immunologiae et therapiae experimentalis - 1 Jan 2000

Urquhart Donald S, Allen Jennifer, Elrayess Mohamed, Fidler Katy, Klein Nigel, Jaffé Adam

Abstract excerpt

INTRODUCTION: Clinical phenotype varies amongst cystic fibrosis (CF) patients with identical CF transmembrane regulator (CFTR) genotype, suggesting genetic modifiers exist. One potential modifier is the Toll-like receptor 4 (TLR4) gene. TLR4 binds lipopolysaccharide (LPS), a constituent of Pseudomonas aeruginosa (PA), activating innate immunity and promoting inflammation. TLR4 polymorphisms are associated with...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16830219
DOI: 10.1007/s00005-006-0029-8

Genes

TLR4
CFTR
FEV

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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