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Article

Association of the ASP299GLY TLR4 polymorphism with COPD.

Respiratory medicine - 1 May 2006

Rohde Gernot, Klein Wolfram, Arinir Umut, Hagedorn Michaela, Duerig Natascha, T Bauer Torsten, Gillissen Adrian, Schultze-Werninghaus Gerhard, T Epplen Jörg

Abstract excerpt

Bacterial infection and colonization plays an important role in COPD. The inflammatory response to these bacteria is mediated by Toll-like receptors. The Asp299Gly polymorphism of the Toll-like receptor-4 (TLR4) has been shown to be associated with decreased lipopolysaccharide (LPS) signal transduction resulting in impaired antimicrobial defense. Because altered TLR4 signalling may facilitate bacterial infection,...

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Source

Identifiers

PMID: 16219455
DOI: 10.1016/j.rmed.2005.08.018

Genes

TLR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Association of the ASP299GLY TLR4 polymorphism with COPD.PMID 16219455Read ↗

TLR4 Asp299Gly and Thr399Ile polymorphisms are very rare in the Chinese population.Semantic proximity Read ↗

Functional consequences of the Asp299Gly Toll-like receptor-4 polymorphism.Semantic proximity Read ↗

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TLR4 mutations are associated with endotoxin hyporesponsiveness in humans.Semantic proximity Read ↗

Association between TLR2/TLR4 gene polymorphisms and COPD phenotype in a Greek cohort.Semantic proximity Read ↗

The role of TLR4 in endotoxin responsiveness in humans.Semantic proximity Read ↗

Synonymous mutations in TLR2 and TLR9 genes decrease COPD susceptibility in the Chinese Han population.Semantic proximity Read ↗

Monocytes heterozygous for the Asp299Gly and Thr399Ile mutations in the Toll-like receptor 4 gene show no deficit in lipopolysaccharide signalling.Semantic proximity Read ↗

Toll-like receptor (TLR) 4 polymorphism Asp299Gly is not associated with disease course in Dutch sarcoidosis patients.Semantic proximity Read ↗

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Association of the TLR4 Asp299Gly polymorphism with lung function in relation to body mass index.Semantic proximity Read ↗

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