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Yellow Fever/Japanese Encephalitis Chimeric Viruses: Construction and Biological Properties

1 Apr 1999

Abstract excerpt

A system has been developed for generating chimeric yellow fever/Japanese encephalitis (YF/JE) viruses from cDNA templates encoding the structural proteins prM and E of JE virus within the backbone of a molecular clone of the YF17D strain. Chimeric viruses incorporating the proteins of two JE strains, SA14-14-2 (human vaccine strain) and JE Nakayama (JE-N [virulent mouse brain-passaged strain]), were studied in...

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PMID: 10074160
DOI: 10.1128/jvi.73.4.3095-3101.1999

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