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Article

FGFR4 Arg388 allele is associated with resistance to adjuvant therapy in primary breast cancer.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 10 Aug 2006

Thussbas Christoph, Nahrig Jorg, Streit Sylvia, Bange Johannes, Kriner Monika, Kates Ronald, Ulm Kurt, Kiechle Marion, Hoefler Heinz, Ullrich Axel, Harbeck Nadia

Abstract excerpt

PURPOSE: A recent study presented first evidence that a single nucleotide polymorphism (SNP) at codon 388 of fibroblast growth factor receptor 4 (FGFR4) gene, causing a transmembrane domain missense mutation (Gly388Arg), is associated with disease outcome in node-positive breast cancer. This article addresses the clinical relevance of this SNP, FGFR4 genotype, phenotype, and HER2 regarding patient outcome and...

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Source

Identifiers

PMID: 16822847
DOI: 10.1200/JCO.2005.04.8587

Genes

FGFR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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FGFR4 Arg388 allele is associated with resistance to adjuvant therapy in primary breast cancer.PMID 16822847Read ↗

FGFR4 Arg388 genotype is associated with pathological complete response to neoadjuvant chemotherapy for primary breast cancer.Semantic proximity Read ↗

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FGFR4 Gly388Arg polymorphism and prognosis of breast and colorectal cancer.Semantic proximity Read ↗

Meta and pooled analyses of FGFR4 Gly388Arg polymorphism as a cancer prognostic factor.Semantic proximity Read ↗

FGFR4 profile as a prognostic marker in squamous cell carcinoma of the mouth and oropharynx.Semantic proximity Read ↗

G388R mutation of the FGFR4 gene is not relevant to breast cancer prognosis.Semantic proximity Read ↗

The fibroblast growth factor receptor 4 (FGFR4) Arg388 allele correlates with survival in head and neck squamous cell carcinoma.Semantic proximity Read ↗

Functional FGFR4 Gly388Arg Polymorphism Predicts Prognosis in Lung Adenocarcinoma PatientsSemantic proximity Read ↗

Is FGFR4 Gly388Arg missense variant a suitable prognostic marker in neuroblastoma?Semantic proximity Read ↗

Prognostic Role of the FGFR4-388Arg Variant in Lung Squamous-Cell Carcinoma Patients With Lymph Node Involvement.Semantic proximity Read ↗

Involvement of the FGFR4 Arg388 allele in head and neck squamous cell carcinoma.Semantic proximity Read ↗

Functional FGFR4 Gly388Arg polymorphism contributes to cancer susceptibility: Evidence from meta-analysis.Semantic proximity Read ↗

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