Article
Determinants for calmodulin binding on voltage-dependent Ca2+ channels.
The Journal of biological chemistry - 15 Dec 2000
Pate P, Mochca-Morales J, Wu Y, Zhang J Z, Rodney G G, Serysheva I I, Williams B Y, Anderson M E, Hamilton S L
Abstract excerpt
Calmodulin, bound to the alpha(1) subunit of the cardiac L-type calcium channel, is required for calcium-dependent inactivation of this channel. Several laboratories have suggested that the site of interaction of calmodulin with the channel is an IQ-like motif in the carboxyl-terminal region of the alpha(1) subunit. Mutations in this IQ motif are linked to L-type Ca(2+) current (I(Ca)) facilitation and...
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