Characterization of HIV-1 envelope gp41 genetic diversity and functional domains following perinatal transmission.

doi:10.1186/1742-4690-3-42

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Article

Characterization of HIV-1 envelope gp41 genetic diversity and functional domains following perinatal transmission.

Retrovirology - 4 Jul 2006

Ramakrishnan Rajesh, Mehta Roshni, Sundaravaradan Vasudha, Davis Tiffany, Ahmad Nafees

Abstract excerpt

BACKGROUND: HIV-1 envelope gp41 is a transmembrane protein that promotes fusion of the virus with the plasma membrane of the host cells required for virus entry. In addition, gp41 is an important target for the immune response and development of antiviral and vaccine strategies, especially when targeting the highly variable envelope gp120 has not met with resounding success. Mutations in gp41 may affect HIV-1...

Topics

Adult
Amino Acid Motifs
Amino Acid Sequence
Child, Preschool
Epitopes, T-Lymphocyte
Evolution, Molecular
Female
Genetic Variation
HIV Envelope Protein gp41
HIV Infections
HIV-1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Infant

Infectious Disease Transmission, Vertical

Male

Molecular Sequence Data

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Phylogeny

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Open in PubMed Open full text

Identifiers

PMID: 16820061
DOI: 10.1186/1742-4690-3-42
PMCID: PMC1526753

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