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Article

Characterization of HIV-1 envelope gp41 genetic diversity and functional domains following perinatal transmission.

Retrovirology - 4 Jul 2006

Ramakrishnan Rajesh, Mehta Roshni, Sundaravaradan Vasudha, Davis Tiffany, Ahmad Nafees

Abstract excerpt

BACKGROUND: HIV-1 envelope gp41 is a transmembrane protein that promotes fusion of the virus with the plasma membrane of the host cells required for virus entry. In addition, gp41 is an important target for the immune response and development of antiviral and vaccine strategies, especially when targeting the highly variable envelope gp120 has not met with resounding success. Mutations in gp41 may affect HIV-1...

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Identifiers

PMID: 16820061
DOI: 10.1186/1742-4690-3-42
PMCID: PMC1526753

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