Article
MDR1 T-129C polymorphism can be predictive of differentiation, and thereby prognosis of colorectal adenocarcinomas in Japanese.
Biological & pharmaceutical bulletin - 1 Jul 2006
Koyama Tatsuya, Nakamura Tsutomu, Komoto Chiho, Sakaeda Toshiyuki, Taniguchi Mayuko, Okamura Noboru, Tamura Takao, Aoyama Nobuo, Kamigaki Takashi, Kuroda Yoshikazu, Kasuga Masato, Kadoyama Keiichi, Okumura Katsuhiko
Abstract excerpt
The expression level of MDR1 mRNA was evaluated in colorectal adenocarcinomas and adjacent noncancerous colorectal tissues obtained from 21 Japanese patients. It was lower in the former than in the latter (p=0.012), suggesting its down-regulation as a consequence of malignant transformation of colorectal tissues, possibly with the suppression of differentiation. Relatively lower expression was suggested in...
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