Article
VEGF T-1498C polymorphism, a predictive marker of differentiation of colorectal adenocarcinomas in Japanese.
International journal of medical sciences - 8 Apr 2008
Yamamori Motohiro, Taniguchi Mayuko, Maeda Shingo, Nakamura Tsutomu, Okamura Noboru, Kuwahara Akiko, Iwaki Koichi, Tamura Takao, Aoyama Nobuo, Markova Svetlana, Kasuga Masato, Okumura Katsuhiko, Sakaeda Toshiyuki
Abstract excerpt
BACKGROUND: Previously, MDR1 T-129C polymorphism, encoding multidrug resistant transporter MDR1/P-glycoprotein, was reported to be predictive of poorly-differentiated colorectal adenocarcinomas. Here, VEGF T-1498C, C-634G and C-7T polymorphisms, encoding vascular endothelial growth factor (VEGF), were investigated in terms of their association with differentiation grade. METHODS: VEGF genotypes were determined by...
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