Article
MDR1 C3435T polymorphism is predictive of later onset of ulcerative colitis in Japanese.
Biological & pharmaceutical bulletin - 1 Feb 2006
Osuga Tatsuya, Sakaeda Toshiyuki, Nakamura Tsutomu, Yamada Toshio, Koyama Tatsuya, Tamura Takao, Aoyama Nobuo, Okamura Noboru, Kasuga Masato, Okumura Katsuhiko
Abstract excerpt
Recently, a silent polymorphism of C3435T of the MDR1 gene, encoding the multidrug resistant transporter MDR1/P-glycoprotein, has been found to be associated with susceptibility to ulcerative colitis (UC), but this remains controversial. This study was conducted to find a possible reason for the discrepancies, and it was suggested that the age of onset was important for the association, namely, C3435T was...
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