Article
ABCB1/MDR1 gene polymorphisms as a prognostic factor in colorectal cancer.
International journal of colorectal disease - 1 Oct 2010
Balcerczak Ewa, Panczyk Mariusz, Piaskowski Sylwester, Pasz-Walczak Grazyna, Sałagacka Aleksandra, Mirowski Marek
Abstract excerpt
OBJECTIVE: To analyse the single-nucleotide polymorphisms (SNPs): ABCB1(1236C>T), ABCB1(2677G>T/A), ABCB1(3435C>T) and haplotypes in the ABCB1/MDR1 gene, which could contribute to genetic risk of colorectal cancer (CRC). Disease association between the ABCB1/MDR1 genotype, allele, haplotype frequencies and histological features, such as TNM classification, localization of primary carcinoma, grade of malignancy,...
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