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Article

Illegitimate V(D)J recombination involving nonantigen receptor loci in lymphoid malignancy

15 Feb 2012

Abstract excerpt

V(D)J recombination of antigen receptor loci (IGH, IGK, IGL, TCRA, TCRB, TCRG, and TCRD) is an essential mechanism that confers enormous diversity to the mammalian immune system. However, there are now at least six examples of intrachromosomal interstitial deletions caused by aberrant V(D)J recombination between nonantigen receptor loci; five of out these six are associated with lymphoid malignancy. The SIL-SCL...

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PMID: 22334400
DOI: 10.1002/gcc.21942

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