Article
Cloning and characterizing mutated human stromal cell-derived factor-1 (SDF-1): C-terminal alpha-helix of SDF-1alpha plays a critical role in CXCR4 activation and signaling, but not in CXCR4 binding affinity.
Experimental hematology - 1 Nov 2006
Tan Yi, Du Jun, Cai Shaoxi, Li Xiaokun, Ma Weifeng, Guo Zhigang, Chen Hongyuan, Huang Zhifeng, Xiao Jian, Cai Lu, Cai Shaohui
Abstract excerpt
OBJECTIVE: A novel C-terminal alpha-helix-defective mutant of human stromal cell-derived factor-1 (SDF-1), hSDF-154, was designed and produced in order to develop an optimal CXC chemokine receptor 4 (CXCR4) antagonist. MATERIALS AND METHODS: Human native SDF-1 and alpha-helix defective SDF-1 (hSD...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.