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Article

CXCR4 dimerization and beta-arrestin-mediated signaling account for the enhanced chemotaxis to CXCL12 in WHIM syndrome.

Blood - 1 Jul 2008

Lagane Bernard, Chow Ken Y C, Balabanian Karl, Levoye Angélique, Harriague Julie, Planchenault Thierry, Baleux Françoise, Gunera-Saad Nathalie, Arenzana-Seisdedos Fernando, Bachelerie Françoise

Abstract excerpt

WHIM (warts, hypogammaglobulinemia, infections, and myelokathexis) syndrome is an immune deficiency linked in many cases to heterozygous mutations causing truncations in the cytoplasmic tail of CXC chemokine receptor 4 (CXCR4). Leukocytes expressing truncated CXCR4 display enhanced responses to the receptor ligand CXCL12, including chemotaxis, which likely impair their trafficking and contribute to the...

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Share to Agammaglobulinemia
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 18436740
DOI: 10.1182/blood-2007-07-102103

Genes

CXCR4
CXCL12

Provenance

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Related research

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