Using yeast to study resistance to topoisomerase II-targeting drugs.

doi:10.1007/BF00684857

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Article

Using yeast to study resistance to topoisomerase II-targeting drugs.

Cancer chemotherapy and pharmacology - 1 Jan 1994

Nitiss J L

Abstract excerpt

We have developed a system utilizing the yeast Saccharomyces cerevisiae to probe the mechanism of action of anti-topoisomerase II drugs. This system has enabled us to dissect the mechanism of action of these agents. By inducing the overexpression of yeast topoisomerase II or by reducing the level...

Topics

Amsacrine
Animals
Drug Design
Drug Resistance, Microbial
Etoposide
Gene Expression
Genes, Fungal
Phenotype
Saccharomyces cerevisiae
Topoisomerase II Inhibitors

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