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Article

Schizosaccharomyces pombe Hst4 functions in DNA damage response by regulating histone H3 K56 acetylation.

Eukaryotic cell - 1 May 2008

Haldar Devyani, Kamakaka Rohinton T

Abstract excerpt

The packaging of eukaryotic DNA into chromatin is likely to be crucial for the maintenance of genomic integrity. Histone acetylation and deacetylation, which alter chromatin accessibility, have been implicated in DNA damage tolerance. Here we show that Schizosaccharomyces pombe Hst4, a homolog of histone deacetylase Sir2, participates in S-phase-specific DNA damage tolerance. Hst4 was essential for the survival...

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Identifiers

PMID: 18344406
DOI: 10.1128/EC.00379-07
PMCID: PMC2394969

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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